The CLL Research Consortium (CRC) is a multi-institutional program project, funded, in part, by the National Institute of Health. The consortium has brought together institutions that, under normal circumstances, would not engage one another as they currently can under the auspices of CRC. The Consortium includes the following clinical sites: Moores UCSD Cancer Center, M.D. Anderson Cancer Center, Ohio State University Cancer Center, Northwell Health, Dana-Farber Cancer Institute, Mayo Clinic, and several sites that perform laboratory work alone, including The Burnham Institute and Barts and the London Cancer Center. These institutions see a diverse patient population and all possess high-quality basic science laboratories. Bringing these sites together in the context of the CRC has resulted in a program that is much more than the sum of its parts.